Male Pattern Baldness Mother

The discovery of two genetic variants of the gene for baldness

In a survey conducted jointly by McGill University, King's College London and GlaxoSmithKline Inc. researchers identified two genetic variants in Caucasians that together are responsible for seven times increased risk of baldness male.

With regard to the male model target = "_blank" title = "Balding"> Baldness it is estimated that one third of all men are affected by the age of 45 years, an impact on those affected both socially and economically. The overall figures show that treatment doctor male pattern baldness has recently surpassed 405 million worldwide while expenditures for hair transplantation in the United States exceeded 115 million (U.S.) in 2007. Androgenetic alopecia is the most common form of baldness in men where hair is lost in a well defined above the first two temples, resulting in a distinctive form of M. In addition, it is estimated that 80% of cases are hereditary.

Dr. Vincent Mooser of GlaxoSmithKline, Dr. Brent Richards of the University McGill of Medicine and the affiliated Jewish General Hospital (and formerly of King's College) and Dr. Tim Spector of King's College, with colleagues in Iceland, Switzerland and the Netherlands Netherlands conducted a study of genome-wide association of 1125 white men, evaluated with male pattern baldness. The study has identified two genetic variants previously unknown on chromosome 20 that have significantly increased the risk of baldness in men. These results helped to confirm the findings of a 1650 more men white.

Richards, assistant professor of genetic epidemiology, argued that it can be assumed that the same genetic variation may be responsible for male pattern baldness and non-Caucasians. However, this reasoning can find no studies have been conducted in these populations.

Although the results of this research can be described as a scientific leap forward, means that almost any treatment or cure for male pattern baldness will be soon.

Richards also said that only one case was identified and the current treatment of male pattern baldness will require more research. However, researchers have managed to cross the first hurdle because the treatment condition may be established after the cause has been identified.

Spector of King's College and director of TwinsUK cohort study, said the hair loss to predict the future before the actual appearance may lead to unconventional therapies are more effective in the treatment of hair loss late stage.

Furthermore, Richards said investigators were aware of a genetic variation on the X chromosome that was linked to male pattern baldness long.

He further clarified that Because of the genetic variant on chromosome X, was supposed baldness is inherited from the maternal side of the family. However, nothing is as straight-jacketed, and it shows that it was not a single gene but several genes are responsible for responsible for male pattern baldness. Until recently, these other genes have been detected. Therefore, if the two variants risk on chromosome 20 and the independent Known variant on the X chromosome is present, the risk of becoming bald increases sevenfold.

It is still more surprising is that 14% of the total population, which is one of the seven men have both variations can.

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