Hair Loss Yeast Infection

Worst breed mix ever?
Okay dog section regulars! With all the “designer mutt” craze, I wonder: what is the absolute worst mixed breed you could think of? (It doesn’t have to be anything that’s been done or even could be done.) Just based on health issues, structural problems, etc., what dogs would you never ever want to see mixed together? Oh, and use the typical pet-store unhealthy-as-sin standards for the breeds, not the well-bred versions.
For example: Westie and Bichon. The badly bred ones of both breeds have AWFUL skin, yeast infections, hot spots, hair loss, allergies, etc. Combining them would practically guarantee severe skin problems. (Not to mention some nasty tear staining.)
What else can you guys think of?
Oh, and please explain WHY the mix would be bad.
I was horrified when I heard that the Jug jack russel X pug often does inherit the jacks hyper activity level and the pugs breathing problems. There apperently ARE jugs that run around till they pass out due to lack of air…..
Immuners Exorcism: 2 — Hair loss
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